Affiliation:
1. Pontifícia Universidade Católica do Rio Grande do Sul, Brazil
Abstract
ABSTRACT Objective: To investigate the correlation between respiratory syncytial viral load and length of hospitalization in infants with acute wheezing episodes. Methods: This was a two-year, cross-sectional study of infants ≤ 12 months of age with bronchiolitis at the time of admission to a tertiary hospital. For the identification of respiratory viruses, nasopharyngeal secretions were collected. Samples were analyzed (throughout the study period) by direct immunofluorescence and (in the second year of the study) by quantitative real-time PCR. We screened for three human viruses: rhinovirus, respiratory syncytial virus, and metapneumovirus. Results: Of 110 samples evaluated by direct immunofluorescence, 56 (50.9%) were positive for a single virus, and 16 (14.5%) were positive for two or more viruses. Among those 72 samples, the most prevalent virus was respiratory syncytial virus, followed by influenza. Of 56 samples evaluated by quantitative real-time PCR, 24 (42.8%) were positive for a single virus, and 1 (1.7%) was positive for two viruses. Among those 25 samples, the most prevalent virus was again respiratory syncytial virus, followed by human rhinovirus. Coinfection did not influence the length of the hospital stay or other outcome s. In addition, there was no association between respiratory syncytial virus load and the length of hospitalization. Conclusions: Neither coinfection nor respiratory syncytial viral load appears to influence the outcomes of acute bronchiolitis in infants.
Subject
Pulmonary and Respiratory Medicine
Reference17 articles.
1. Childhood wheezing;Sole D.;J Bras Pneumol,2008
2. Respiratory symptoms and asthma in relation to cold climate, inhaled allergens, and irritants a comparison between northern and southern Finland;Kotaniemi JT;J Asthma,2002
3. Prevalence of and risk factors for wheezing in the first year of life;Lima JA;J Bras Pneumol,2010
4. Severity of viral coinfection in hospitalized infants with respiratory syncytial virus infection;De Paulis M;J Pediatr (Rio J),2011
5. Severe lower respiratory tract infection in infants and toddlers from a non-affluent population viral etiology and co-detection as risk factors;da Silva ER;BMC Infect Dis,2013
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