Affiliation:
1. Federal University of Espirito Santo, Brazil
2. Federal University of Pelotas, Brazil
Abstract
OBJECTIVE: To analyze the association between clinical/epidemiological characteristics and outcomes of tuberculosis treatment in patients with concomitant tuberculosis and chronic kidney disease (CKD) in Brazil. METHODS: We used the Brazilian Ministry of Health National Case Registry Database to identify patients with tuberculosis and CKD, treated between 2007 and 2011. The tuberculosis treatment outcomes were compared with epidemiological and clinical characteristics of the subjects using a hierarchical multinomial logistic regression model, in which cure was the reference outcome. RESULTS: The prevalence of CKD among patients with tuberculosis was 0.4% (95% CI: 0.37-0.42%). The sample comprised 1,077 subjects. The outcomes were cure, in 58%; treatment abandonment, in 7%; death from tuberculosis, in 13%; and death from other causes, in 22%. The characteristics that differentiated the ORs for treatment abandonment or death were age; alcoholism; AIDS; previous noncompliance with treatment; transfer to another facility; suspected tuberculosis on chest X-ray; positive results in the first smear microscopy; and indications for/use of directly observed treatment, short-course strategy. CONCLUSIONS: Our data indicate the importance of sociodemographic characteristics for the diagnosis of tuberculosis in patients with CKD and underscore the need for tuberculosis control strategies targeting patients with chronic noncommunicable diseases, such as CKD.
Subject
Pulmonary and Respiratory Medicine
Reference30 articles.
1. CKD: a pandemic calling for concerted public health action;Saran R;Adv Chronic Kidney Dis,2010
2. The aging pandemic: demographic changes in the general and end-stage renal disease populations;Eggers PW;Semin Nephrol,2009
3. A new mechanism of humoral immunodepression in chronic renal failure and its importance to dialysis and transplantation;Donnelly PK;Proc Eur Dial Transplant Assoc,1983
4. Infections in patients with chronic renal failure and kidney transplant recipients in Brazil;Bedendo J;Prog Transplant,2011
5. Tuberculosis;Lawn SD;Lancet,2011
Cited by
11 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献