Estimated glomerular filtration rate in clinical practice: Consensus positioning of the Brazilian Society of Nephrology (SBN) and Brazilian Society of Clinical Pathology and Laboratory Medicine (SBPC/ML)

Author:

Kirsztajn Gianna Mastroianni1ORCID,Silva Junior Geraldo Bezerra da2ORCID,Silva Artur Quintiliano Bezerra da3ORCID,Abensur Hugo4ORCID,Romão Junior João Egídio4ORCID,Bastos Marcus Gomes5ORCID,Calice-Silva Viviane6ORCID,Carmo Lilian Pires de Freitas do7,Sandes-Freitas Tainá Veras de8ORCID,Abreu Patrícia Ferreira1,Andreguetto Bruna Dolci9,Cortes Luiz Gustavo Ferreira10ORCID,Oliveira Maria Gabriela de Lucca9,Vieira Luisane Maria Falci11,Moura-Neto José A.12ORCID,Andriolo Adagmar13ORCID

Affiliation:

1. Sociedade Brasileira de Nefrologia, Brazil; Universidade Federal de São Paulo, Brazil

2. Sociedade Brasileira de Nefrologia, Brazil; Centro de Ciências da Saúde, Brazil

3. Sociedade Brasileira de Nefrologia, Brazil; Universidade Federal do Rio Grande do Norte, Brazil

4. Sociedade Brasileira de Nefrologia, Brazil; Universidade de São Paulo, Brazil

5. Sociedade Brasileira de Nefrologia, Brazil; Faculdade de Ciências Médicas e da Saúde de Juiz de Fora, Brazil; Faculdade Ubaense Ozanam Coelho, Brazil

6. Sociedade Brasileira de Nefrologia, Brazil; Universidade da Região de Joinville, Brazil; Fundação Pró-Rim, Brazil

7. Sociedade Brasileira de Nefrologia, Brazil; Universidade Federal de Minas Gerais, Brazil

8. Sociedade Brasileira de Nefrologia, Brazil; Universidade Federal do Ceará, Brazil

9. Universidade Federal de São Paulo, Brazil

10. Sociedade Brasileira de Patologia Clínica e Medicina Laboratorial, Brazil; Hospital Israelita Albert Einstein, Brazil

11. Sociedade Brasileira de Patologia Clínica e Medicina Laboratorial, Brazil; Dasa – Diagnósticos da América S.A., Brazil

12. Sociedade Brasileira de Nefrologia, Brazil; Escola Bahiana de Medicina e Saúde Pública, Brazil

13. Universidade Federal de São Paulo, Brazil; Sociedade Brasileira de Patologia Clínica e Medicina Laboratorial, Brazil

Abstract

ABSTRACT Chronic kidney disease (CKD) represents one of today’s main public health problems. Serum creatinine measurement and estimation of the glomerular filtration rate (GFR) are the main tools for evaluating renal function. There are several equations to estimate GFR, and CKD-EPI equation (Chronic Kidney Disease – Epidemiology) is the most recommended one. There are still some controversies regarding serum creatinine measurement and GFR estimation, since several factors can interfere in this process. An important recent change was the removal of the correction for race from the equations for estimating GFR, which overestimated kidney function, and consequently delayed the implementation of treatments such as dialysis and kidney transplantation. In this consensus document from the Brazilian Societies of Nephrology and Clinical Pathology and Laboratory Medicine, the main concepts related to the assessment of renal function are reviewed, as well as possible existing controversies and recommendations for estimating GFR in clinical practice.

Publisher

FapUNIFESP (SciELO)

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