Cytokines as determinants of disease and disease interactions

Author:

Sher A.1,Gazzinelli R.T.2,Jankovic D.1,Scharton-Kersten T.1,Yap G.1,Doherty T.M.1,Wynn T.1

Affiliation:

1. National Institutes of Health

2. National Institutes of Health; Universidade Federal de Minas Gerais

Publisher

FapUNIFESP (SciELO)

Subject

Cell Biology,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Immunology,Physiology,Biochemistry,General Neuroscience,Biophysics

Reference11 articles.

1. In the absence of endogenous IL-10 mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-g and TNF-a;Gazzinelli RT;Journal of Immunology,1996

2. Defects in cell-mediated immunity affect chronic, but not innate resistance of mice to Mycobacterium avium infection;Doherty TM;Journal of Immunology,1997

3. Production of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection;Sher A;Journal of Immunology,1991

4. Cytokine control of parasite-specific anergy in human urinary schistosomiasis: IL-10 modulates lymphocyte reactivity;King CL;Journal of Immunology,1996

5. Analysis of granuloma formation in double cytokine deficient mice reveals a central role for IL-10 in polarizing both Th1 and Th2-type cytokine responses in vivo;Wynn TA;Journal of Immunology,1998

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