Affiliation:
1. Campus Capão do Leão, Brasil
2. Universidade Federal do Rio Grande - FURG, Brasil
3. Universidade Federal de Pelotas - UFPEL, Brasil
Abstract
Visceral toxocariasis is a neglected zoonosis caused byToxocara canis larvae in unusual hosts. In dogs, the definitive host, the infection occurs mainly through transplacental and transcolostral transmission. Studies on experimental models have shown that vertical transmission may result from acute infections. Considering that toxocariasis is characterized as a chronic infection, with possible reactivation of larvae present in the brain, this study evaluated the presence of larvae in the brain of female BALB/c mice and their offspring with chronic infection during three successive pregnancies. ELISA-TES was used to evaluate the antibody levels. T. canis larvae were detected in the brain tissue of the mice during the three successive generations evaluated. The offspring's IgG level gradually decreased, and mean absorbance (ABS) above the cutoff point (0.070) was observed only at 30 (0.229) and 50 (0.096) days of age, while IgM was not detected. The infections in the offspring confirmed that vertical transmission of T. canis larvae occurred during chronic toxocariasis in three successive generations of mice.
Subject
General Veterinary,Parasitology
Reference28 articles.
1. The migration of larval Toxocara canis in mice. II. Post-intestinal migration in primary infections;Abo-Shehada MN;Vet Parasitol,1984
2. Toxocariasis in Waste Pickers: A Case Control Seroprevalence Study;Alvarado-Esquivel C;PLoS One,2013
3. Warning about potential for congenital neural larva migrans;Anderson BC;J Am Vet Med Assoc,1996
4. Registro da transmissão vertical em camundongos BALB/c com toxocarose crônica;Avila LFC;Vittalle,2009
5. The nature of visceral larva migrans;Beaver PC;J Parasitol,1969
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