Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an immune response

Author:

Dang N.N.1,Pang S.G.2,Song H.Y.2,An L.G.3,Ma X.L.2

Affiliation:

1. Jinan Central Hospital Affiliated to Shandong University, China; College of Life Science, Shandong Normal University, China

2. Jinan Central Hospital Affiliated to Shandong University, China

3. College of Life Science, Shandong Normal University, China

Publisher

FapUNIFESP (SciELO)

Subject

Cell Biology,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Immunology,Physiology,Biochemistry,General Neuroscience,Biophysics,General Medicine

Reference27 articles.

1. Hyperproduction of IFN-gamma by CpG oligodeoxynucleotide-induced exacerbation of atopic dermatitis-like skin lesion in some NC/Nga mice;Takakura M;J Invest Dermatol,2005

2. New insights into the epidemiology of childhood atopic dermatitis;Flohr C;Allergy,2014

3. Crosstalk between keratinocytes and T cells in a 3D microenvironment: a model to study inflammatory skin diseases;van den Bogaard EH;J Invest Dermatol,2014

4. Serum levels of Th2 chemokines, CCL17, CCL22, and CCL27, were the important markers of severity in infantile atopic dermatitis;Nakazato J;Pediatr Allergy Immunol,2008

5. Characterization of two distinct calcium-binding sites in the amino-terminus of human profilaggrin;Presland RB;J Invest Dermatol,1995

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