Morphological and biomechanical study of abdominal aorta of rats submitted to experimental chronic alcoholism

Author:

Cerqueira Nereide Freire1,Yoshida Winston Bonetti1,Müller Sérgio Swain1,Sequeira Júlio Lopes1,Rodrigues Antônio de Castro2,Padovani Carlos Roberto1

Affiliation:

1. UNESP

2. USP

Abstract

PURPOSE: To assess the influence of experimental chronic alcoholism in the morphology and biomechanics of the aorta, in a rat model. METHODS: Forty-four Wistar rats were randomly divided into two groups of 22 animals each: in the alcoholism group, the rats received water mixed to increasing concentrations of ethyl alcohol; and control group: the rats received pure water for 180 days. The animals were then killed by an overdose of pentobarbital and the abdominal aortas were excised for histological (hematoxylin-eosin, Masson, Calleja, and Picrosirius red stain), histomorphometrical, and biomechanical analysis. RESULTS: Histology and histomorphometry did not show differences in aorta morphology of both groups. Biomechanical analysis showed a significantly greater yield point elongation in the alcoholic rat group (p<0.05). CONCLUSION: Chronic alcoholism did not cause morphological alterations in the aortic wall but increased elongation, without modifying any other mechanical properties.

Publisher

FapUNIFESP (SciELO)

Subject

Surgery

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