Affiliation:
1. Federal University of São Paulo
2. Medicine School of Bahia
Abstract
Presentation of an experimental model to study the effect of nicotine in a random skin flap, in the rat. Adult rats of the same lineage are exposed to nicotine for seven days in the preoperative period. After the preoperative period, the animals are anesthetized and a dorsal random pattern skin flap, cranially based is elevated. On the seventh postoperative day, the rats are anesthetized and the percentages of distal necrosis in the flaps are determined. After that, excision of skin fragments for biochemical analysis is possible. Blood samples may be collected by decapitation.
Reference13 articles.
1. Skin flap failure: pathophysiology;Kerrigan CL;Plast Reconstr Surg,1983
2. Interrupção do uso da nicotina nos retalhos cutâneos randomizados em ratos;Campos JHO,2001
3. The design of a pedicle flap in the rat to study necrosis and its prevention;Mc Farlane RM;Plast Reconstr Surg.,1965
4. Flaps and flaps necrosis;Ugland O;Acta Chir Scand.,1966
5. Hemodynamics and viability of acute neurovascular island skin flaps in rats;Sasaki GH;Plast Reconstr Surg.,1980
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献