Experimental model of induction of diabetes mellitus in rats

Author:

Carvalho Eliziane Nitz de1,Carvalho Nestor Antônio Schmidt de2,Ferreira Lydia Masako3

Affiliation:

1. Federal University of São Paulo

2. UNIVALI, Brazil

3. UNIFESP, Brazil

Abstract

Diabetes mellitus is a potentially morbid condition with high prevalence worldwide, thus being a major medical concern. Experimental models play an important role in understanding such a disease, which is treatable only. This study describes a rat diabetes mellitus model induced by administering a reduced dose of alloxan, thus greatly reducing the animals’ death rate.

Publisher

FapUNIFESP (SciELO)

Subject

Surgery

Reference14 articles.

1. Role of metabolic control on diabetic nephorathy;Macedo CS;Acta Cir Bras,2002

2. Diabetes mellitus;Halpern A;Rev Bras Med,2000

3. Campanha de prevenção e diagnóstico do diabetes realizada pela UNIARARAS e prefeitura municipal na cidade de Araras;Beretta ALRZ;Laes & Haes,2001

4. Tratado de fisiologia aplicada a ciências da saúde;Cisternas JR,2000

5. Long Term Effects of Aloxan in Mice;Ahrén R;Int J Pancreatol,1995

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