Proliferative effect of aqueous extract of Hyptis fructicosa on liver regeneration after partial hepatectomy in rats

Author:

Lima Sônia Oliveira1,Viana Luciano da Costa,Santana Fábio Rafael Teixeira de,Zucoloto Ségio2,Albuquerque Junior Ricardo Luiz de1,Gomes Margarete Zanardo1

Affiliation:

1. Tiradentes University, Brazil

2. Sao Paulo University, Brazil

Abstract

PURPOSE: To evaluate the effect of aqueous extract of Hyptis fructicosa on hepatic regeneration after partial hepatectomy in rats. METHODS: Sixteen rats were divided in two groups: C (Control Group) and HF (Whose rats received aqueous extract of Hyptis fructicosa during 4 days using the dose of 100 mg/kg/day). On the consecutive day of this treatment, the animals of both groups underwent hepatectomy of about 67% of liver. Twenty four hours later, they were sacrificed, and the remaining mass of liver was removed and prepared to be studied through the PCNA immunohistochemical technique. RESULTS: The liver regeneration index of HF group was 53.56 ± 18.91%, while in C group was 21.12 ± 8.29% (p=0.0003). CONCLUSION: These results show that the administration of aqueous extract of Hyptis fructicosa using the dose of 100mg/kg/day increased the hepatocyte proliferation in the group HF.

Publisher

FapUNIFESP (SciELO)

Subject

Surgery

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