Affiliation:
1. Tiradentes University, Brazil
2. Sao Paulo University, Brazil
Abstract
PURPOSE: To evaluate the effect of aqueous extract of Hyptis fructicosa on hepatic regeneration after partial hepatectomy in rats. METHODS: Sixteen rats were divided in two groups: C (Control Group) and HF (Whose rats received aqueous extract of Hyptis fructicosa during 4 days using the dose of 100 mg/kg/day). On the consecutive day of this treatment, the animals of both groups underwent hepatectomy of about 67% of liver. Twenty four hours later, they were sacrificed, and the remaining mass of liver was removed and prepared to be studied through the PCNA immunohistochemical technique. RESULTS: The liver regeneration index of HF group was 53.56 ± 18.91%, while in C group was 21.12 ± 8.29% (p=0.0003). CONCLUSION: These results show that the administration of aqueous extract of Hyptis fructicosa using the dose of 100mg/kg/day increased the hepatocyte proliferation in the group HF.
Reference30 articles.
1. Check-list of the Family Lamiaceae in Pernambuco, Brazil;Almeida CFCBR;Braz Arch Biol Technol.,2002
2. Avaliação do efeito antinociceptivo e da toxicidade aguda do extrato aquoso da Hyptis fruticosa Salmz;Silva ABL;ex Benth. Rev Bras Farmacogn.,2006
3. Antimicrobial substances of superior plants. 45. Primary observations of 2 new quinoids isolated from Hyptis fructicosa Salzm ex Benth (Labiatae);Araújo MD;Rev Inst Antibiot.,1974
4. Wound healing property of ethanolic extract of leaves of Hyptis suaveolens with supportive role of antioxidant enzymes;Shirwaikar A;Indian J Exp Biol.,2003
5. Antimicrobial activity of Hyptis ovalifolia towards dermatophytes;Souza LKH;Mem Inst Oswaldo Cruz.,2003
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献