Expression of RANTES, eotaxin-2, ICAM-1, LFA-1 and CCR-3 in chronic rhinosinusitis patients with nasal polyposis-Reference-Cited by-同舟云学术

Expression of RANTES, eotaxin-2, ICAM-1, LFA-1 and CCR-3 in chronic rhinosinusitis patients with nasal polyposis

Published:2012-09 Issue:9 Volume:27 Page:645-649
ISSN:0102-8650
Container-title:Acta Cirurgica Brasileira
language:
Short-container-title:Acta Cir. Bras.

Author:

Cavallari Fransérgio Emílio¹,Valera Fabiana Cardoso Pereira¹,Gallego Aline Jorge¹,Malinsky Rafael Rossell¹,Küpper Daniel Salgado¹,Milanezi Cristiane¹,Silva João Santana da¹,Tamashiro Edwin¹,Anselmo-Lima Wilma Terezinha¹

Affiliation:

1. USP, Brazil

Abstract

PURPOSE: To compare gene expression of the chemokines RANTES and eotaxin-2, its receptor, CCR-3, adhesion molecule ICAM-1 and its receptor LFA-1 in eosinophilic polyps and in control normal nasal mucosa. METHODS: Gene expression was quantified by Real Time PCR in polyps (n=35) and in healthy nasal mucosa (n=15). RESULTS: Eosinophilic polyps showed a higher expression of eotaxin-2 and RANTES, but not of CCR-3, ICAM-1 or LFA-1 compared to control nasal mucosa. CONCLUSION: Eosinophilic polyps present greater expression of eotaxin-2 and RANTES, but not of CCR-3, ICAM-1 or LFA-1 compared to control nasal mucosa.

Publisher

FapUNIFESP (SciELO)

Subject

Surgery

Link

http://www.scielo.br/pdf/acb/v27n9/v27n9a10.pdf

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