Experimental evidence of pharmacological management of anchorage in Orthodontics: A systematic review

Author:

Fernández-González Felipe José1,Cañigral Aránzazu2,Balbontín-Ayala Felipe3,Gonzalo-Orden José Manuel4,Carlos Felix de1,Cobo Teresa1,Fernández-Vázquez Jose Pedro1,Sánchez-Lasheras Fernando1,Vega José Antonio1

Affiliation:

1. University of Oviedo, Spain

2. University of Valencia, Spain

3. University of Andes, Chile

4. University of León, Spain

Abstract

Introduction: Orthodontic anchorage is one of the most challenging aspects of Orthodontics. Preventing undesired movement of teeth could result in safer and less complicated orthodontic treatment. Recently, several reviews have been published about the effects of different molecules on bone physiology and the clinical side effects in Orthodontics. However, the effects of local application of these substances on the rate of orthodontic tooth movement have not been assessed.Objectives: The aim of this research was to analyze the scientific evidence published in the literature about the effects of different molecules on orthodontic anchorage.Methods: The literature was systematically reviewed using PubMed/Medline, Scopus and Cochrane databases from 2000 up to July 31st, 2014. Articles were independently selected by two different researchers based on previously established inclusion and exclusion criteria, with a concordance Kappa index of 0.86. The methodological quality of the reviewed papers was performed.Results: Search strategy identified 270 articles. Twenty-five of them were selected after application of inclusion/exclusion criteria, and only 11 qualified for final analysis. Molecules involved in orthodontic anchorage were divided into three main groups: osteoprotegerin (OPG), bisphosphonates (BPs) and other molecules (OMs).Conclusions: Different drugs are able to alter the bone remodeling cycle, influencing osteoclast function and, therefore, tooth movement. Thus, they could be used in order to provide maximal anchorage while preventing undesired movements. OPG was found the most effective molecule in blocking the action of osteoclasts, thereby reducing undesired movements.

Publisher

FapUNIFESP (SciELO)

Subject

Oral Surgery,Orthodontics

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. In-vitro investigation of primary stability of orthodontic mini implants with different lengths using resonance frequency analysis;Journal of Contemporary Orthodontics;2023-01-15

2. Anchorage;Preadjusted Edgewise Fixed Orthodontic Appliances;2021-09-24

3. Non-conventional methods for accelerating orthodontic tooth movement. A contemporary overview;Orthodontic Update;2021-04-02

4. Biological Orthodontics;Biological Mechanisms of Tooth Movement;2021-03-10

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