Affiliation:
1. Universidade Estadual Paulista, Brasil; Universidade de São Paulo, Brasil
2. Universidade Estadual Paulista, Brasil
3. Universidade de São Paulo, Brasil; Universidade de São Paulo, Brasil
Abstract
Abstract Visceral leishmaniasis (VL) is a disease caused by the protozoa Leishmania infantum and can cause an inflammatory reaction in the gastrointestinal tract, however the role of granulocytic cells (neutrophils, eosinophils, and mast cells) in the intestine of dogs infected is not fully understood. We performed a quantitative analysis these cells in the intestinal wall of dogs with canine visceral leishmaniasis (CVL). Twenty dogs were assigned to one of three groups: group 1 (G1, n=8), dogs with CVL and L. infantum amastigotes in the intestine; group 2 (G2, n=9), dogs with CVL but without intestinal amastigotes; and group 3 (G3, n=3), uninfected dogs (control group). Granulocytic cells were counted in the crypt-villus unit (mucosa), submucosa, and muscle layer of the intestinal mucosa. Cell counts were higher in the intestinal wall of dogs from G2 followed by G1 and G3 (p≤0.05). In G1, there was a low inverse correlation between parasite burden of the small intestine and granulocyte counts (r= -0.1, p≤0.01). However, in G2 dogs, mast cell and eosinophil numbers showed positive correlation (r=0.85, p≤0.01). The granulocytic cell hyperplasia observed in the intestine of L. infantum-infected dogs suggests that these cells may be involved in the cell-mediated immune response for parasite elimination.
Subject
General Veterinary,Parasitology
Reference52 articles.
1. Soluble IL-2 receptor as an agent of serum mediated suppression in human visceral leishmaniasis;Barral-Netto M;J Immunol,1991
2. Atypical Forms of Canine Leishmaniosis;Blavier A;Vet J,2001
3. Association between mast cells, tissue remodelation and parasite burden in the skin of dogs with visceral leishmaniasis;Cardoso JMO;Vet Parasitol,2017
4. Current Veterinary Therapy: IX Small Animal Practice.;Chiapella A,1986
5. A retrospective clinical study of canine leishmaniasis in 150 dogs naturally infected by Leishmania infantum.;Ciaramella P;Vet Rec,1997
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献