Anthelmintic efficacy of oxibendazole against gastrointestinal nematodes in swine

Author:

Mendonça Rafael Paranhos de1,Carneiro Daniela Oliveira2,Baccin Eliane Marucci2,Pirágine Márcia Richena2,Zoca Sara Menegatti2,Rossa Luis Augusto Ferreira2,Lima Guilherme Cecílio1,Oliveira Francismar Barbosa de2,Costa Istanlei Soares2,Oliveira Gabriel Nunes de1,Nogueira Sabrina Nathália Louzada2,Santos-Doni Thaís Rabelo dos3ORCID

Affiliation:

1. Universidade de Franca, Brasil

2. , Brasil

3. Universidade Federal dos Vales do Jequitinhonha e Mucuri, Brasil

Abstract

Abstract In swine production, parasites, especially gastrointestinal helminths, generate considerable economic losses. Therefore, effective control measures, such as the use of the correct anthelmintics, are of paramount importance for maintaining profitability. The aim of the present study was to evaluate the efficacy of the anthelmintic oxibendazole, administered orally, in pigs (non-industrial) naturally infected with gastrointestinal nematodes. To that end, we selected 18 pigs naturally parasitized by gastrointestinal nematodes, as determined by examination of fecal samples (eggs per gram (EPG > 500) of feces), and divided them into two groups: treated (with a 10-day course of oxibendazole) and control (untreated). After the treatment period, the animals were euthanized. During necropsy, the helminths in the gastrointestinal tract were identified and quantified. The species identified were, in order of occurrence, Ascaris suum, Trichuris suis, Oesophagostomum dentatum, and Hyostrongylus rubidus. In Brazilian swine herds, traditional (non-industrial) production systems can favor the transmission of helminths. We found that treatment with oxibendazole was 100% effective against A. suum and H. rubidus, whereas it was 99.65% effective against O. dentatum and 99.20% effective against T. suis, significantly reducing helminth counts (P < 0.01 for all). We conclude that oxibendazole is effective in controlling the main helminths in swine.

Publisher

FapUNIFESP (SciELO)

Subject

General Veterinary,Parasitology

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