Affiliation:
1. Universidade Federal do Paraná
2. UNICAMP
3. Hospital das Nações
Abstract
The authors describe a family with three members affected by glioblastoma. The proband patient, a 7 year-old girl, developed a rare complication, a pulmonary metastasis. Chromosomal analysis of her peripheral blood lymphocytes showed a normal karyotype (46, XX), without structural abnormalities. Cytogenetic study of the tumor cells disclosed several abnormalities: 46, XX, 7q - / 46, XX, -2, 4p-, 7p-, +15/ 46, XX. Some aspects about genetics of glial neoplasms are discussed.
Subject
Neurology,Neurology (clinical)
Reference23 articles.
1. DNA content and chromosomal composition of malignant human gliomas;Bigner SH;Neurol Clin,1985
2. Specific chromosomal abnormalities in malignant human gliomas;Bigner SH;Cancer,1988
3. Molecular genetics of human cancer predisposition and progression;Cavenee WK;Mutat Res,1991
4. Familial brain tumors: studies of two families and review of recent literature;Challa VR;Neurosurgery,1983
5. Evidence for a tumor supressor gene on chromosome 19q associated with human astrocytomas, oligodendrogliomas, and mixed gliomas;Deimling A;Cancer Res,1992
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献