Statin and fibrate associed myopathy: study of eight patients

Author:

Carvalho Alzira A. Siqueira1,Lima Ürsula Waleska Poti2,Valiente Raul Alberto2

Affiliation:

1. Hospital Santa Marcelina, Brasil; Myogenética, Clínica de Doenças Neuromusculares, Brasil

2. Hospital Santa Marcelina, Brasil

Abstract

Lipid-lowering drugs have been occasionally associated with neuromuscular symptoms and muscle biopsy changes. We reported the clinical course and the muscle biopsy in eight patients with hyperlipoproteinemia, treated with lipid -lowering drugs (statins/fibrates). Five patients had myalgias while; in two cases there was proximal muscle weakness. All patients became asymptomatic after the withdrawal of the drug, although creatine kinase remained elevated. We performed muscle biopsy in six cases from three months to two years after suspension of the drug. We found variation in fibers diameters in all cases, with necrosis of fibers in five cases, inflammatory infiltration in one case, the presence of vacuolated fiber in one patient and ragged-red fibers in three subjects. We concluded that although the muscle biopsy findings were not specific, the prolonged use of statins and or fibrates might induce a chronic myopathy even in the absence of symptoms.

Publisher

FapUNIFESP (SciELO)

Subject

Neurology,Clinical Neurology

Reference18 articles.

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2. Statin-associated myopathy;Hamilton-Craig I;Med J Aust,2001

3. Lipid-lowering drugs and mitochondrial function: effects of HMG Co A reductase inhibitors on serum ubiquinone and blood lactate/ pyruvate ratio;Pinieux G;Bri J Clin Pharmacol,1996

4. Statin-associated myopathy;Thompson PD;JAMA,2003

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