Malignant transformation of pleomorphic xanthoastrocytoma: case report

Author:

Tella Jr Oswaldo Ignácio de1,Herculano Marco Antonio2,Prandini Mirto Nelso1,Stavale João Norberto3,Aguiar Paulo Henrique4

Affiliation:

1. Federal University of São Paulo

2. Jundiai Medicine School, Brazil

3. Federal University of São Paulo, Brazil

4. State University of São Paulo, Brazil

Abstract

We report a case of a pleomorphic xantoastrocytoma which manifested itself as a cystic isodense lesion in the right fronto-temporal lobe in a 26 year-old woman. It appeared as a soft yellow tumor with cystic cavities on surgery. Five months after this surgery, the patient was submitted to a new operation, which revealed a friable tumor, easily differentiated from the normal parenchyma, with cystic components. The histopathological examination demonstrated pleomorphic xanthoastrocytoma with malignant transformation. Histologically, the tumor at first procedure was composed of pleomorphic astrocytes with multinucleated and foamy cells. A rare case of malignant transformation in pleomorphic xanthoastrocytoma is presented, discussed and illustrated in this paper.

Publisher

FapUNIFESP (SciELO)

Subject

Neurology,Neurology (clinical)

Reference12 articles.

1. Pleomorphic xanthoastrocytoma: a distinctive meningocerebral glioma of young subjects with relatively favorable prognosis: a study of 12 cases;Kepes JJ;Cancer,1979

2. Pleomorphic xanthoastrocytoma: the birth of a diagnosis and a concept;Kepes JJ;Brain Pathol,1993

3. Increased mitotic activity as a negative prognostic indicator in pleomorphic xanthoastrocytoma: case report;MacCaulay RJ;J Neurosurg,1993

4. Cerebro-meningeal pleomorphic xanthoastrocytoma: report on four cases. Clinical, radiologic and pathological features (including a case with malignant evolution);Allegranza A;Neurosurgery,1991

5. A case of anaplastic astrocytoma transformed from pleomorphic xanthoastrocytoma;Daita G;Brain Tumor Pathol,1991

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