Quantitative study of the myenteric plexus of the stomach of rats with streptozotocin-induced diabetes

Author:

Fregonesi Cristina Elena Prado Teles1,Miranda-Neto Marcílio Hubner de2,Molinari Sônia Lucy2,Zanoni Jacqueline Nelisis2

Affiliation:

1. Universidade Estadual Paulista, Brasil

2. Universidade Estadual de Maringá

Abstract

The purpose of the present study was to investigate the morphological and quantitative alterations of the myenteric plexus neurons of the stomach of rats with streptozotocin-induced chronic diabetes and compare them to those of non-diabetic animals. Samples from the body of the stomach were used for whole-mount preparations stained with NADH-diaphorase and for histological sections stained with hematoxylin-eosin. It was observed that diabetes cause a significant decrease on the number of neurons.

Publisher

FapUNIFESP (SciELO)

Subject

Neurology,Clinical Neurology

Reference20 articles.

1. Diabetic autonomic neuropathy;Hosking DJ;Diabetes,1978

2. Autonomic neuropathy in the streptozotocin diabetic rat;Monckton G;Can J Neurol Sci,1980

3. Myenteric plexus in streptozotocin-treated rats: neurochemical and histochemical evidence for diabetic neuropathy in the gut;Lincoln J;Gastroenterology,1984

4. Varied effects of experimental diabetes on the autonomic nervous system of the rat;Kniel PC;Lab. Invest.,1986

5. Gastric emptying in diabetic autonomic neuropathy;Campbell IW;Gut,1977

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