Affiliation:
1. Federal University of São João del-Rei, Brasil
Abstract
SUMMARY Obesity, diabetes and hypertension are risk factors for cardiovascular diseases (CVD) because they promote a state of hypercoagulability. It is known that platelets play an important role in the development of atherosclerosis. Recent studies have evaluated platelet volume indexes (PVIs) in individuals with risk factors for CVD to better understand the platelet mechanisms involved in their development. The IVPs indirectly estimate platelet function and are easily obtained from automated hematology analyzers, which provide platelet counts, mean platelet volume (MPV), platelet distribution width (PDW) and the platelet-large cell ratio (P-LCR). The present study aims to review literature studies that investigated the association between PVIs and obesity, diabetes, and arterial hypertension, in order to evaluate its use as a potential subclinical marker of CVD. Studies have shown promising results for MPV, an index that allows for early detection of platelet activation and may be useful in identifying patients before the onset of CVD development so that preventive strategies can be implemented. The PDW, although evaluated by a smaller number of studies, also showed promising results. However, there is still a long way to go in order for the MPV and PDW to be used in clinical practice, since there is still a need for more epidemiological evidence, establishing reference values, and standardizing the way results are presented.
Reference37 articles.
1. Global Atlas on Cardiovascular Disease Prevention and Control;Mendis S,2011
2. Physiopathology and inflammatory aspects of atherosclerosis;Gottlieb MGV;Scientia Médica,2005
3. The role of platelets in atherothrombosis;Kaplan ZS;Hematology Am Soc Hematol Educ Program,2011
4. The determination of a reference range for new platelet parameters produced by the Bayer ADVIA 120 full blood count analyser;Brummitt DR;Clin Lab Haematol,2000
5. The causal role of megakaryocyte-platelet hyperactivity in acute coronary syndromes;Martin JF;Nat Rev Cardiol,2012
Cited by
24 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献