A single nucleotide polymorphism, rs129679860, in the IL28B locus is associated with the viral kinetics and a sustained virological response in a chronic, monoinfected hepatitis C virus genotype-1 Brazilian population treated with pegylated interferon-ribavirin

Author:

Ramos Juliene Antonio1,Ramos Ana Lúcia de Araújo2,Hoffmann Luisa3,Perez Renata de Mello2,Coelho Henrique Sérgio Moraes2,Ürményi Turán Péter3,Silva Rosane3,Rondinelli Edson4,Villela-Nogueira Cristiane Alves2

Affiliation:

1. Universidade Federal do Rio de Janeiro, Brasil; Instituto de Educação, Ciência e Tecnologia do Rio de Janeiro, Brasil; Ministério da Ciência e Tecnologia, Brasil

2. Universidade Federal do Rio de Janeiro, Brasil

3. Universidade Federal do Rio de Janeiro, Brasil; Ministério da Ciência e Tecnologia, Brasil

4. Universidade Federal do Rio de Janeiro, Brasil; Universidade Federal do Rio de Janeiro, Brasil; Ministério da Ciência e Tecnologia, Brasil

Publisher

FapUNIFESP (SciELO)

Subject

Microbiology (medical)

Reference32 articles.

1. Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients;Abe H;J Hepatol,2010

2. IL28B and the control of hepatitis C virus infection;Balagopal A;Gastroenterology,2010

3. IL28B alleles associated with poor hepatitis C virus (HCV) clearance protect against inflammation and fibrosis in patients infected with non-1 HCV genotypes;Bochud PY;Hepatology,2012

4. IL28B polymorphisms are marked of the therapy response and are influenced by genetic ancestry in chronic hepatitis C patients from an admixed population;Cavalcante LN;Liver Int,2012

5. Pharmacodynamics of PEG-IFN-[alpha]-2α and HCV response as a function of IL28B polymorphism in HIV/HCV coinfected patients;de Araujo ES;J Acquir Immune Defic Syndr,2011

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