USE OF TRANEXAMIC ACID IN ADULTS SCOLIOSIS SURGERY: SYSTEMATIC REVIEW AND META-ANALYSIS

Abstract

ABSTRACT To evaluate the effects of using tranexamic acid in scoliosis surgeries in adults. This meta-analysis considered bleeding as the main outcome, using the Mantel-Haenszel fixed model. Cochran’s Q test was also used, whose null hypothesis is that the studies that make up the meta-analysis are homogeneous. After applying the exclusion criteria, seven of the eight papers previously selected were included in the statistical analyses, adding up to 911 patients (76 to 355 patients). The incidence rates of efficacy among experimentally treated patients were a geometric mean of 45%. Concerning blood loss, mean values were 1302 ± 490 in the control group versus 1108 ± 150 mL in the experimental group. Biological factors such as male gender and type of surgery did not influence the protective outcome of tranexamic acid in terms of reducing bleeding (p > 0.05). Age over 65 was statistically significant (p = 0.04) using the x2 test. This meta-analytical study showed that age over 65 is a factor that negatively influences the effects of tranexamic acid in reducing bleeding in scoliosis correction surgeries. Level of Evidence I; Randomized and Controlled Clinical Studies with homogeneous results.