ENERGY SUPPLY AND DEMAND IN THE INTERVERTEBRAL DISC

Author:

Bardonova Liudmila Andreevna1ORCID,Sheikh Omar2ORCID,Malova Irina Olegovna1ORCID,Sorokovikov Vladimir Alexeevich3ORCID,Byvaltsev Vadim Anatolyevich1ORCID

Affiliation:

1. Irkutsk State Medical University, Russia

2. Oregon State University, USA

3. Irkutsk Scientific Center of Surgery and Traumatology, Russia

Abstract

ABSTRACT The intervertebral disc (IVD) is one of the parts of the body most commonly affected by disease, and it is only recently that we have come closer to understanding the reasons for its degeneration, in which nutrient supply plays a crucial role. In this literature review, we discuss the basic principles and characteristics of energy supply and demand to the IVD. Specifically, we review how different metabolites influence IVD cell activity, the effects of mechanical loading on IVD cell metabolism, and differences in energy metabolism of the annulus fibrous and nucleus pulposus cell phenotypes. Determining the factors that influence nutrient supply and demand in the IVD will enhance our understanding of the IVD pathology, and help to elucidate new therapeutic targets for IVD degeneration treatment.

Publisher

FapUNIFESP (SciELO)

Subject

Neurology (clinical),Orthopedics and Sports Medicine,Surgery

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