Cutaneous leukocytoclastic vasculitis in the presence of methimazole therapy

Author:

Ribeiro Carla de Oliveira1,Magrin Paula Ferrazzi1,Vilar Enoí Aparecida Guedes1,Durães Sandra Maria Barbosa1,Estrella Rogério Ribeiro1

Affiliation:

1. Universidade Federal Fluminense, Brazil

Abstract

Treatment with antithyroid drugs may be accompanied by side effects. We present a patient diagnosed with Grave's Disease who developed extensive vasculitis in the lower limbs during methimazole use. After suspension of the methimazole and the introduction of prednisone in immunesupressor doses the cutaneous lesions started to involute.

Publisher

FapUNIFESP (SciELO)

Subject

Dermatology

Reference10 articles.

1. Antithyroid drugs;Cooper DS;N Engl J Med,2005

2. Antineutrophil cytoplasmic antibody-positive vasculitis in a patient with Grave´s Disease: cross-reaction between propylthiouracil and methimazole;Ahmed K;Endocr Pract,2010

3. Frequency of antineutrophil cytoplasmic antibody in Graves' Disease patients treated with methimazole;Gumà M;J Clin Endocrinol Metab,2003

4. Clinical case seminar: anti-thyroid drugs and antineutrophil cytoplasmic antibody positive vasculitis. A case report and review of the literature;Gunton JE;J Clin Endocrinol Metab,1999

5. Antineutrophil cytoplasmic antibody (Anca)-associated autoimmune disease induced by propylthiouracil;Pietszkowski NC;Arq Bras Endocrinol Metab,2007

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