Abstract
PURPOSE: Analyze the ability of Acetylcysteine to reduce distal necrosis in a random skin flap, in the rat. METHODS: The present study utilized 28 adult male Wistar-EPM rats distributed, at random, in two groups of 14 animals. Control group rats (CG) received distilled water and Acetylcysteine group animals (NACG) received NAC (300 mg/kg) by oral infusion, 15 minutes before flap elevation. On the seventh postoperative day, percentage of distal necrosis was determined and skin samples collected in order to allow determination of MDA levels. RESULTS: The mean necrotic area in CG group (control) was 66 % and in NACG group (Acetylcysteine) 52 %, a statistically significant difference according to the Mann-Whitney test (U calc = 25; U crit = 45). MDA levels were lower in the CG flap skin samples than in the NACG samples (U calc = 24; U crit = 45), the oposite being true in the normal skin samples (U calc = 10; U crit = 45). CONCLUSION: Acetylcysteine was effective, according to the model used, reducing the percentage of distal necrosis in NACG rats.
Reference10 articles.
1. The effect of cigarette smoking on skin-flap survival in the face lift patient;Rees TD;Plast Reconstr Surg.,1984
2. Association between cutaneous occlusive vascular disease, cigarette smoking, and skin slough after rhytidectomy;Riefkohl R;Plast Reconstr Surg.,1986
3. Effect of Acetylcysteine in a random skin flap after administration of nicotine, in the rat;Gomes HC;Folha Med.,1998
4. Effect of Dimethyl sulphoxide on necrosis of skin flaps in rats;Duarte IS;Can J Plast Surg.,1998
5. Effect of Acetylcysteine on the pulmonary response to endotoxin in the awake sheep and upon in vitro granulocyte function;Bernard GR;J Clin Ivest.,1984
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