Affiliation:
1. Instituto OswaldoInstituto OswaldoInstituto Oswaldo, Brasil
2. Universidade Federal da Bahia
3. Universidade de São Paulo, Brasil; WashingtonWashingtonWashington, USA
Abstract
A sample of 502 individuals from 94 families from Jacobina, State of Bahia, Brazil, was investigated to determine the causal mechanisms involved in Leishmania chagasi (the causal agent of visceral leishmaniasis in the American hemisphere) infection, as measured by the intradermic reaction to antigens derived from this parasite, using complex segregation analyses. The results showed evidence of a major genetic mechanism acting on infection, with a frequency of a recessive (or additive) susceptibility gene (q) of approximately 0.45. A small multifactorial component (H = 0.29) acting in conjunction with a major recessive gene (q = 0.37) is not ruled out as a concomitant causative factor.
Subject
Genetics,Molecular Biology
Reference55 articles.
1. Detection of major genes for susceptibility to leprosy and its subtypes in a Caribbean island: Desirade;Abel L.;Am. J. Hum. Genet.,1988
2. Complex segregation analysis of leprosy in Southern Vietnam;Abel L.;Genet. Epidemiol.,1995
3. Susceptibility to leprosy is linked to the Human NRAMP1 gene;Abel L.;J. Infect. Dis.,1998
4. A new look at the statistical model identification;Akaike H.;IEEE Trans. Automatic Control AC,1974
5. Mapping Creb-1 to chromosome one in the mouse;Barton C.H.;Genomics
Cited by
13 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献