Chemical constituents of Aspergillus sp EJC08 isolated as endophyte from Bauhinia guianensis and their antimicrobial activity

Author:

Pinheiro Eduardo A.A.1,Carvalho Josiwander M.1,Santos Diellem C.P. dos1,Feitosa Andre O.1,Marinho Patricia S.B.1,Guilhon Giselle Maria S.P.1,Santos Lourivaldo S.1,Souza Afonso L.D. de2,Marinho Andrey M.R.1

Affiliation:

1. Universidade Federal do Para, Brasil

2. Universidade Federal do Amazonas, Brasil

Abstract

The present work reports the isolation of five compounds from Aspergillus sp EJC08 isolated as endophytic from Bauhinia guianensis, a tipical plant of the Amazon. The compounds ergosterol (1), ergosterol peroxide (2), mevalolactone (3), monomethylsulochrin (4) and trypacidin A (5) were isolated by chromatographic procedures and identified by spectral methods of 1D and 2D NMR and MS. Compounds 3, 4 and 5 were tested against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus and showed good activity.

Publisher

FapUNIFESP (SciELO)

Subject

Multidisciplinary

Reference13 articles.

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3. The Structure of Trypacidin;BALAN J;Acta Chem Scand,1965

4. Produtos naturais como ponto de partida para a descoberta de novas substâncias bioativas: Candidatos a fármaco com ação antiofídica, anticâncer e antiparasitária;COSTA PRR.;Rev Virtual Quim,2009

5. Medicinal natural products: a biosynthetic approach;DEWICK PM.,1997

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