Evaluation of Bcl-2, Bcl-x and Cleaved Caspase-3 in Malignant Peripheral Nerve Sheath Tumors and Neurofibromas-Reference-Cited by-同舟云学术

Evaluation of Bcl-2, Bcl-x and Cleaved Caspase-3 in Malignant Peripheral Nerve Sheath Tumors and Neurofibromas

Published:2013-11-10 Issue:4 Volume:85 Page:1497-1511
ISSN:0001-3765
Container-title:Anais da Academia Brasileira de Ciências
language:
Short-container-title:An. Acad. Bras. Ciênc.

Author:

CUNHA KARIN S.¹,CARUSO ANABELA C.²,FARIA PAULO A.³,SILVA LICINIO E. DA¹,FONSECA ELIENE C. DA¹,GELLER MAURO⁴,MOURA-NETO RODRIGO S. DE⁵,LOPES VANIA S.¹

Affiliation:

1. Universidade Federal Fluminense, Brasil

2. Servico de Anatomia Patologica, Brasil

3. Divisao de Patologia, Brasil

4. Centro Universitario Serra dos Orgaos/UNIFESO, Brasil

5. Universidade Federal do Rio de Janeiro, Brasil

Abstract

AIMS: To study the expression of Bcl-2, Bcl-x, as well the presence of cleaved caspase-3 in neurofibromas and malignant peripheral nerve sheath tumors. The expression of Bcl-2 and Bcl-x and the presence of cleaved caspase 3 were compared to clinicopathological features of malignant peripheral nerve sheath tumors and their impact on survival rates were also investigated. MATERIALS AND METHODS: The evaluation of Bcl-2, Bcl-x and cleaved caspase-3 was performed by immunohistochemistry using tissue microarrays in 28 malignant peripheral nerve sheath tumors and 38 neurofibromas. Immunoquantification was performed by computerized digital image analysis. CONCLUSIONS: Apoptosis is altered in neurofibromas and mainly in malignant peripheral nerve sheath tumors. High levels of cleaved caspase-3 are more common in tumors with more aggressive histological features and it is associated with lower disease free survival of patients with malignant peripheral nerve sheath tumors.

Publisher

FapUNIFESP (SciELO)

Subject

Multidisciplinary

Link

http://www.scielo.br/pdf/aabc/v85n4/0001-3765-aabc-00-00-8413.pdf

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