Improving survival in children with AIDS in Brazil: results of the second national study, 1999-2002

Author:

Matida Luiza Harunari1,Ramos Jr. Alberto Novaes2,Heukelbach Jorg2,Sañudo Adriana3,Succi Regina Célia de Menezes4,Marques Heloisa Helena de Sousa3,Negra Marinella Della5,Hearst Norman

Affiliation:

1. Secretaria de Estado da Saúde de São Paulo, Brasil

2. Universidade Federal do Ceará, Brasil

3. Universidade de São Paulo, Brasil

4. Universidade Federal de São Paulo, Brasil

5. University of California, USA

Abstract

The objective of this study is to characterize survival in children with AIDS diagnosed in Brazil between 1999-2002, compared with the first national study (1983-1998). This national retrospective cohort study examined a representative sample of Brazilian children exposed to HIV from mother-to-child transmission and followed through 2007. The survival probability after 60 months was analyzed by sex, year of birth and death, clinical classification, use of antiretroviral therapy (ART) and prophylaxis for opportunistic diseases. 920 children were included. The survival probability increased: comparing cases diagnosed before 1988 with those diagnosed from 2001-2002 it increased by 3.5-fold (from 25% to 86.3%). Use of ART, initial clinical classification, and final classification were significant (p < 0.001) predictors of survival. Issues regarding quality of records and care were identified. The results point to the success of the Brazilian policy of providing ART. The improvement of clinical status contributes to quality of life, while indicating challenges, particularly practices to improve long-term care.

Publisher

FapUNIFESP (SciELO)

Subject

Public Health, Environmental and Occupational Health

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