Chemotherapy protocols and incidence of oral mucositis. An integrative review

Author:

Curra Marina1,Soares Junior Luiz Alberto Valente2,Martins Manoela Domingues3,Santos Paulo Sérgio da Silva2

Affiliation:

1. Universidade de Caxias do Sul, Brazil

2. Universidade de São Paulo, Brazil

3. Universidade Federal do Rio Grande do Sul, Brazil

Abstract

ABSTRACT This review aimed to analyze the scientific production on severity of oral mucositis as an adverse effect of chemotherapy. To this end, we performed a search at PubMed databases combining the keywords “oral mucositis” and “chemotherapy protocol”. To describe the investigation, the following variables were considered: journal, year/place, study design, sample, protocol used and incidence of oral mucositis. A total of 547 articles were retrieved, of which 26 were selected. Out of these 26, only 2 reported severity of oral mucositis; the others only reported the presence of the condition. Protocols for treating different types of carcinoma were evaluated in 16 (61.53%) studies, for hematological malignancies in 6 (23.07%), and for hematopoietic stem cell transplantation in 4 (15.4%). Protocols for hematopoietic stem cell transplantation entail a high risk for oral mucositis, just as chemotherapy with cytarabine and high-dose 5-fluorouracil, alkylating agents and platinumbased compounds. To provide the best prevention and treatment for oral mucositis, it is essential to know the chemotherapy protocols used and their effects on the oral cavity.

Publisher

FapUNIFESP (SciELO)

Subject

General Medicine

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