Cognitive and balance dysfunctions due to the use of zolpidem in the elderly: a systematic review

Author:

Tavares Guilherme1ORCID,Kelmann Gizela1ORCID,Tustumi Francisco2ORCID,Tundisi Catherine Nardini1ORCID,Silveira Bárbara Regina Bruço1ORCID,Barbosa Bruno Maximiliano Augusto Colombo1ORCID,Winther Diana Bragança1ORCID,Boutros Eduarda Conte1ORCID,Villar Gabriel dos Santos1ORCID,Brunocilla Giovanna1ORCID,Lourenção Gustavo Rodrigues Caldas1ORCID,Ferreira Jiulia Giovanna Aranha1ORCID,Bernardo Wanderley Marques3ORCID

Affiliation:

1. Department of Evidence-Based Medicine, Brazil

2. Department of Evidence-Based Medicine, Brazil; Department of Evidence-Based Medicine, Brazil; Department of Surgery, Brazil

3. Department of Evidence-Based Medicine, Brazil; Department of Evidence-Based Medicine, Brazil

Abstract

ABSTRACT. Zolpidem is one of the most widely prescribed hypnotic (non-benzodiazepine) agents for sleep disorder. Recently, an increase in the demand for this drug has been observed, mainly in the elderly population. Objective: This study aims to analyze the acute effect of zolpidem on cognitive and balance dysfunctions in the elderly population. Methods: A study was conducted by two independent researchers in four virtual scientific information bases and included randomized controlled trials. The studies evaluated elderly patients using zolpidem. Cognitive and balance dysfunctions were analyzed. Results: Six articles were included. The mean age of the participants in the studies was 69 years. The following zolpidem dosages were evaluated: 5, 6.25, 10, and 12.5 mg. Comparing zolpidem and placebo, relating to the cognitive dysfunctions, there is no statistically significant difference between the groups. However, in relation to balance dysfunctions, there is a statistically significant difference between the intervention and the comparison, favoring placebo. Conclusions: Zolpidem, even in usual doses (5 mg and 10 mg), has shown to increase the risk for balance dysfunctions. However, this does not occur in relation to cognitive changes.

Publisher

FapUNIFESP (SciELO)

Subject

Cognitive Neuroscience,Geriatrics and Gerontology,Clinical Neurology,Neurology,Sensory Systems

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