Affiliation:
1. Federal University of Rio de Janeiro, Brazil
2. University of California, USA; University of Sao Paulo, Brazil
Abstract
Alois Alzheimer is best known for his description of the pre-senile neurodegenerative disease named after him. However, his previous interest in vascular brain diseases, underlying cognitive and behavioral changes, was very strong. Besides describing the Arteriosclerotic atrophy of the brain and the arteriosclerotic subtype of Senile dementia which he viewed as main forms of vascular brain diseases, he also identified and described a series of conditions he considered subforms. These may be divided, as suggested by the authors of the present paper, into 3 groups: gliosis and sclerosis, subcortical atrophies, and apoplectic. The subforms of the three groups present characteristic neuropathological features and clinical, cognitive and behavioral manifestations. These provide the basis, together with part of the main forms, for the contemporary condition known as Vascular Cognitive Impairment.
Subject
Cognitive Neuroscience,Geriatrics and Gerontology,Clinical Neurology,Neurology,Sensory Systems
Reference30 articles.
1. Alzheimer's 100th anniversary of death and his contribution to a better understanding of Senile dementia;Engelhardt E;Arq Neuropsiquiatr,2015
2. Alzheimer and vascular brain disease: the Arteriosclerotic atrophy of the brain;Engelhardt E;Dement Neuropsychol,2015
3. Alzheimer and vascular brain disease: Senile dementia;Engelhardt E;Dement Neuropsychol,2015
4. Die arteriosklerotische Atrophie des Gehirns;Alzheimer A;Neurol Centralbl,1894
5. Bericht über 5 Fälle bezeichnet als perivasculäre Gliose;Alzheimer A;Centralbl Nervenheilk Psychiat,1896