Diagnosis of Alzheimer’s disease: recommendations of the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology

Author:

Schilling Lucas Porcello1ORCID,Balthazar Marcio Luiz Figueredo2ORCID,Radanovic Márcia3ORCID,Forlenza Orestes Vicente4ORCID,Silagi Marcela Lima5ORCID,Smid Jerusa3ORCID,Barbosa Breno José Alencar Pires6ORCID,Frota Norberto Anízio Ferreira7ORCID,Souza Leonardo Cruz de8ORCID,Vale Francisco Assis Carvalho9ORCID,Caramelli Paulo8ORCID,Bertolucci Paulo Henrique Ferreira10ORCID,Chaves Márcia Lorena Fagundes11ORCID,Brucki Sonia Maria Dozzi3ORCID,Damasceno Benito Pereira2ORCID,Nitrini Ricardo3ORCID

Affiliation:

1. Pontifícia Universidade do Rio Grande do Sul, Brasil; Pontifícia Universidade do Rio Grande do Sul, Brasil; Pontifícia Universidade do Rio Grande do Sul, Brasil

2. Universidade Estadual de Campinas, Brasil

3. Universidade de São Paulo, Brasil

4. Universidade de São Paulo, Brasil; Universidade de São Paulo, Brasil

5. Universidade Federal de São Paulo, Brasil; Universidade de São Paulo, Brasil

6. Universidade de São Paulo, Brasil; Universidade Federal de Pernambuco, Brasil; Instituto de Medicina Integral Prof. Fernando Figueira, Brasil

7. Hospital Geral de Fortaleza, Brasil; Universidade de Fortaleza, Brasil

8. Universidade Federal de Minas Gerais, Brasil

9. Universidade Federal de São Carlos, Brasil

10. Universidade Federal de São Paulo, Brasil

11. Hospital de Clínicas de Porto Alegre, Brasil; Universidade Federal do Rio Grande do Sul, Brasil

Abstract

ABSTRACT This paper presents the consensus of the Scientific Department of Cognitive Neurology and Aging from the Brazilian Academy of Neurology on the diagnostic criteria for Alzheimer’s disease (AD) in Brazil. The authors conducted a literature review regarding clinical and research criteria for AD diagnosis and proposed protocols for use at primary, secondary, and tertiary care levels. Within this clinical scenario, the diagnostic criteria for typical and atypical AD are presented as well as clinical, cognitive, and functional assessment tools and complementary propaedeutics with laboratory and neuroimaging tests. The use of biomarkers is also discussed for both clinical diagnosis (in specific conditions) and research.

Publisher

FapUNIFESP (SciELO)

Subject

Cognitive Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Neurology,Sensory Systems

Reference139 articles.

1. World Alzheimer Report 2021: Journey through the diagnosis of dementia;Gauthier S,2021

2. Dementias in Brazil: increasing burden in the 2000-2016 period. Estimates from the Global Burden of Disease Study 2016;Melo SC;Arq Neuropsiquiatr,2020

3. Recent progress in Alzheimer's disease research, part 2: genetics and epidemiology;Robinson M;J Alzheimers Dis,2017

4. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission;Livingston G;Lancet,2020

5. Genetics of Alzheimer's disease;Kim JH;Dement Neurocogn Disord,2018

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