CIRCULATING GHRELIN LEVELS AND SUSCEPTIBILITY TO COLORECTAL CÂNCER

Author:

ASADI Asadollah1ORCID,FARAHANI Hamid2ORCID,MAHMOUDI Touraj3ORCID,TABAEIAN Seidamir Pasha4ORCID,REZAMAND Gholamreza5ORCID,MOHAMMADBEIGI Abolfazl2ORCID,DABIRI Reza6ORCID,NOBAKHT Hossein6ORCID,REZVAN Sajad7ORCID,MOHAMMADI Fatemeh2ORCID

Affiliation:

1. University of Mohaghegh Ardabili, Iran

2. Qom University of Medical Sciences, Iran

3. Shahid Beheshti University of Medical Sciences, Iran

4. Iran University of Medical Sciences, Iran; Iran University of Medical Sciences, Iran

5. Iran University of Medical Sciences, Iran

6. Semnan University of Medical Sciences, Iran

7. Rafsanjan University of Medical Sciences, Iran

Abstract

ABSTRACT BACKGROUND AND OBJECTIVE: Considering the association between colorectal cancer (CRC) and both insulin resistance and obesity, and the prominent role of ghrelin in these metabolic disorders, we explored whether plasma levels of ghrelin were associated with CRC. Moreover, in the patients with CRC the possible correlations between ghrelin and insulin, insulin resistance, and body mass index (BMI) as an indicator of obesity were examined. METHODS: A total of 170 subjects, including 82 cases with CRC and 88 controls were enrolled in this study. Plasma levels of ghrelin, insulin, and glucose were measured in all the subjects using ELISA and glucose oxidase methods. Furthermore, insulin resistance was assessed by calculating HOMA-IR index. RESULTS: The cases with CRC had decreased ghrelin levels (P<0.001) and a higher HOMA-IR index (P<0.001) than controls. Interestingly, when CRC patients were stratified based on tumor site, lower ghrelin levels and a higher HOMA-IR index were observed in the patients with either colon or rectal cancer vs. controls too. Additionally, there were an age and BMI-independent negative correlation between ghrelin levels and HOMA-IR (r=-0.365, P<0.05), and an age-independent negative correlation between ghrelin levels and BMI (r=-0.335, P<0.05) in the rectal subgroup. CONCLUSION: Our findings support a role for ghrelin in connection with insulin resistance and obesity in CRC susceptibility; however, it needs to be corroborated by further studies.

Publisher

FapUNIFESP (SciELO)

Subject

Gastroenterology

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