Affiliation:
1. Federal University of Paraná, Brazil
Abstract
Osmotic demyelination syndrome (ODS) may be precipitated by aggressive correction of a hypo or hyper-osmolar states. We describe the case of a 53-year-old woman that was started on fluoxetine 20 mg/day for depression and nine days later was found to have fluoxetine-induced syndrome of inappropriate secretion of antidiuretic hormone. After hyponatremia correction the mental status of the patient gradually improved, but subsequently she had intermittent difficulty in speaking, naming objects, memory deficits and psychomotor slowness. Magnetic resonance revealed bilateral symmetric hyperintense lesions in the basal ganglia, temporal lobe and hippocampal formation compatible with ODS. These symptoms gradually resolved and she was discharged home without any deficits. Two months later, a new image showed lesion in pons and the other lesions had disappeared. Fluoxetine therapy had never been related with a complication like that.
Subject
Neurology,Neurology (clinical)
Reference28 articles.
1. Central pontine myelinolysis: a hitherto undescribed disease occurring in alcoholic and malnourished patients;Adams RD;AMA Arch Neurol Psychiatry,1959
2. Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone associated with the use of selective serotonin reuptake inhibitors: a review of spontaneous reports;Liu BA;CMAJ,1996
3. Severe hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with fluoxetine;Twardowschy CA;Arq Neuropsiquiatr,2006
4. Myelinolysis after correction of hyponatremia;Laureno R;Ann Intern Med,1997
5. Central pontine and extra-pontine myelinosis in alcoholic patient with Shoshin beriberi;Aguiar AC;Arq Neuropsiquiatr,2004
Cited by
13 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献