Affiliation:
1. Marília Medical School, Brazil
2. University of São Paulo
Abstract
OBJECTIVE: To evaluate the neuroprotective effect of mild hypothermia during temporary focal ischemia in cats. METHOD: 20 cats underwent middle cerebral artery 60 minutes occlusion and 24 hours reperfusion: 10 under normothermia and 10 under mild hypothermia (32º C). Brain coronal sections 2mm thick were stained with 2,3,5-triphenyltetrazolium hydrochloride, photographed and evaluated with software for volume calculation. RESULTS:Cortical ischemia was found in 7 and basal ganglia ischemia in 8 animals of group 1 and in both regions in 5 animals of group 2 (no difference: p=0.6499 for cortical; p=0.3498 for basal ganglia). No ischemia was found in 5 animals of group 2 and in none of group 1 (significant difference, p=0.0325). The infarct volume was greater in group 1 than 2 (p=0.0433). CONCLUSION: Mild hypothermia did not interfere with location of ischemia, but it was effective for reducing the infarct volume.
Subject
Neurology,Clinical Neurology
Reference26 articles.
1. Mild hypothermia, hypertension, and mannitol are protective against infarction during experimental intracranial temporary vessel occlusion;Ogilvy CS;Neurosurgery,1993
2. Therapeutic hypothermia for acute stroke;Olsen TS;Lancet Neurol,2003
3. Hypothermia and stroke: the pathophysiological background;Schaller B;Pathophysiology,2002
4. Brain cooling during transient focal ischemia provides complete neuroprotection;Barone FC;Neurosci Behav Rev,1997
5. Effects of intraischemic hypothermia on cerebral damage in a model of reversible focal ischemia;Goto Y;Neurosurgery,1993
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