Affiliation:
1. Universidade de São Paulo, Brasil; Hospital Alemão Oswaldo Cruz, Brasil
Abstract
ABSTRACT Intrahepatic biliary proliferations represent a spectrum from reactive (ductular reaction, some with atypical architecture), hamartomatous (von Meyenburg complex), benign (bile duct adenoma) and precursor/borderline entities (biliary intraepithelial neoplasia, intraductal papillary neoplasm of the bile duct) to fully malignant (cholangiocarcinoma) neoplasms. Clinical pictures and even imaging patterns may be similar, requiring refined studies aiming at histopathological and immunohistochemistry for more precise diagnosis, essential for correct patient management. This article discusses updated concepts and definitions of most relevant entities aiming more specifically at the differential diagnosis in practice, focusing on morphology and immunohistochemistry, with a discussion of potential markers to help distinguishing between benign and malignant lesions.
Reference80 articles.
1. WHO classification of tumours series,2019
2. Up-to-Date Pathologic Classification and Molecular Characteristics of Intrahepatic Cholangiocarcinoma;Chung T;Front Med,2022
3. Congenital diseases of intrahepatic bile ducts: variations on the theme “ductal plate malformation”;Desmet VJ;Hepatology,1992
4. Tumors and Tumor-Like Lesions of The Hepatobiliary Tract;Zimmermann A,2017
5. MacSween’s Pathology of the Liver;Ferrell L,2018