Muscle biopsy correlated with electromyography: study of 100 cases

Author:

Werneck Lineu Cesar1,Lima José Geraldo Camargo1

Affiliation:

1. Universidade Federal do Paraná; Escola Paulista de Medicina

Abstract

To find what the correlation is and verify if is possible to avoid extensive electromyographic examination, studying only one muscle, 100 patients with neuromuscular disorders (58 primary myopathies, 32 neurogenic disorders and 10 myotonic dystrophies) were submited to quantified electromyography (EMG) and muscle biopsy (MB) with fresh-frozen section plus histochemistry in the same muscle, but on the opposite side. The EMG was abnormal in 98% and MB in 93% of the cases. EMG and MB had a concordance of 84.3% in the neurogenic disorders and 84.77% in the primary myopathies. A correlation of 80% was obtained between all MB and EMG (including the cases of myotonic dystrophies), regarding the origin of the pathogenic process (p<0.01). The EMG had 5% inconsistences and the MB 11%, with respect to the pathogenic process. When the myotonic dystrophy was separated from the primary myopathies and from the denervation disorders, a complete concordance was found in all MB and had only 3.4% inconsistences in the denervation disorders and 3.1% in the primary myopathies.

Publisher

FapUNIFESP (SciELO)

Subject

Neurology,Clinical Neurology

Reference59 articles.

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3. Pathogenesis of respiratory insuficiency in myotonic dystrophy: the mechanical factors;Begin R;Am Rev Resp Dis,1982

4. Diagnostic accuracy of clinical data, quantitative electromyography and histochemistry in neuromuscular disease: a study of 105 cases;Black JT;J Neurol Sci,1974

5. Further observations on the histologic response of rat skeletal muscle to EMG fine wire-electrodes: significance of insulation;Blanton PL;Electromyography,1971

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