Brain SPECT imaging in Huntington's disease before and after therapy with olanzapine: case report

Author:

ETCHEBEHERE ELBA C. S. C.1,LIMA MARIANA C. L.1,PASSOS WALMIR1,MACIEL JR JAIME A.1,SANTOS ALLAN O.1,RAMOS CELSO DARÍO1,CAMARGO EDWALDO E.1

Affiliation:

1. Universidade Estadual de Campinas (UNICAMP)

Abstract

Olanzapine, an atypical antipsychotic drug, was administered to a patient with Huntington's disease (HD) with marked choreiform movements. Brain SPECT with 99mTc-HMPAO was performed before and after treatment. Brain SPECT imaging has been performed in patients with HD in order to determine the status of basal ganglia perfusion. The use of brain SPECT with 99mTc-HMPAO before and after treatment in patients with HD has not been yet reported. The marked hypoperfusion of the basal ganglia on brain SPECT performed before therapy with olanzapine improved significantly after treatment.

Publisher

FapUNIFESP (SciELO)

Subject

Neurology,Neurology (clinical)

Reference7 articles.

1. Single photon emission computed tomographic blood flow and magnetic resonance volume imaging of basal ganglia in Huntington's disease;Harris GJ;Arch Neurol,1996

2. The scintigraphic evaluation of Huntington's disease and other movement disorders using single photon emission computed tomography perfusion brain scans;Nagel JS;Semin Nucl Med,1991

3. Iodine-123-IBZM dopamine D2 receptor and technetium-99m-HMPAO brain perfusion SPECT in the evaluation of patients with and subjects at risk for Huntington's disease;Ichise M;J Nucl Med,1993

4. SPECT with HMPAO compared to PET with FDG in Huntington disease;Boecker H;J Comput Assist Tomogr,1994

5. [SPECT studies with 99mTc-HMPAO in Huntington's chorea patients;Botsch H;ROFO Fortschr Geb Rontgenstr Nuklearmed,1987

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