Acute psychotic disorders induced by topiramate: report of two cases

Author:

Stella Florindo1,Caetano Dorgival2,Cendes Fernando3,Guerreiro Carlos A.M.3

Affiliation:

1. Universidade Estadual Paulista, Brasil

2. Universidade Estadual de Campinas, Brasil

3. Universidade Estadual de Campinas

Abstract

We report on two epileptic patients who developed acute psychosis after the use of topiramate (TPM). One patient exhibited severe psychomotor agitation, heteroaggressiveness, auditory and visual hallucinations as well as severe paranoid and mystic delusions. The other patient had psychomotor agitation, depersonalization, derealization, severe anxiety and deluded that he was losing his memory. Both patients had to be taken to the casualty room. After interruption of TPM in one patient and reduction of dose in the other, a full remission of the psychotic symptoms was obtained without the need of antipsychotic drugs. Clinicians should be aware of the possibility of development of acute psychotic symptoms in patients undergoing TPM treatment.

Publisher

FapUNIFESP (SciELO)

Subject

Neurology,Neurology (clinical)

Reference30 articles.

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3. The topiramate YD Study Group;Faught E;Neurology,1996

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5. Preliminary open-label experience with topiramate in primary generalized seizures;Biton V;Epilepsia,1997

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