Different effects of scopolamine on learning, memory, and nitric oxide metabolite levels in hippocampal tissues of ovariectomized and Sham-operated rats-Reference-Cited by-同舟云学术

Different effects of scopolamine on learning, memory, and nitric oxide metabolite levels in hippocampal tissues of ovariectomized and Sham-operated rats

Published:2012-06 Issue:6 Volume:70 Page:447-452
ISSN:0004-282X
Container-title:Arquivos de Neuro-Psiquiatria
language:
Short-container-title:Arq. Neuro-Psiquiatr.

Author:

Azizi-Malekabadi Hamid¹,Hosseini Mahmoud²,Soukhtanloo Mohammad²,Sadeghian Reihaneh³,Fereidoni Masoud³,Khodabandehloo Fatimeh⁴

Affiliation:

1. Islamic Azad University, Khorasgan Branch, Iran

2. Mashhad University of Medical Sciences, Iran

3. Ferdowsi University of Mashhad, Iran

4. AJA University of Medical Sciences, Iran

Abstract

Different effects of scopolamine on learning, memory, and nitric oxide (NO) metabolites in hippocampal tissues of ovariectomized (OVX) and sham-operated rats were investigated. The animals in the Sham-Scopolamine (Sham-Sco) and OVX-Scopolamine (OVX-Sco) Groups were treated with 2 mg/kg scopolamine before undergoing the Morris water maze, while the animals in the Sham and OVX Groups received saline. The time latency and path length were significantly higher in both the Sham-Sco and the OVX-Sco Groups, in comparison with the Sham and OVX Groups, respectively (p<0.001). Significantly lower NO metabolite levels in the hippocampi of the Sham-Sco Group were observed, compared with the Sham Group (p<0.001), while there was no significant difference between the OVX-Sco and OVX Groups. The decreased NO level in the hippocampus may play a role in the learning and memory deficits induced by scopolamine. However, it seems that the effect of scopolamine on hippocampal NO differs between situations of presence and absence of ovarian hormones.

Publisher

FapUNIFESP (SciELO)

Subject

Neurology,Clinical Neurology

Link

http://www.scielo.br/pdf/anp/v70n6/12.pdf

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