Affiliation:
1. School of Medicine
2. State University of São Paulo, Brazil
Abstract
The aim of the present investigation was to study the distribution of T-cell subsets in peripheral blood defined by monoclonal antibodies and by the lymphocyte proliferative response to phytohemagglutinin (PH A) in 30 children with febrile seizures and in 14 age-matched control subjects. Frequent respiratory, urinary and dermatologic infections were observed in 22 patients. The immunologic parameters showed that 64% of the patients presented an increased number of CD8+ cells and a low helper/suppressor ratio was observed in 60% of the patients. In addition, the proliferative response of lymphocytes to PHA was impaired in the patients. It was observed the presence of inhibitory activity on lymphocyte function in the plasma of 33% of children with febrile seizures. These results suggest that patients with febrile seizures have an impairment of cellular immunity that may be connected with this epileptic syndrome and explain the infections observed.
Subject
Neurology,Clinical Neurology
Reference24 articles.
1. On the clinical relevance of psychoneuroimmunology;Ader R;Clin Immunol Immunopathol,1992
2. Relevance of a family history of seizures;Baraitser M;Arch Dis Child,1983
3. Consensus Statement: Febrile Seizures: Long-term management of children with fever-associated seizures;Pediatrics,1980
4. Kelley KW: Stress and immunity: an integrated view of the relationship between the brain and the immune system;Dantzer R;Life Sci,1989
5. Osterland CK, Guttman RD, Andermann F, Pichal JF, Andermann E, Jangua NA: Immunological studies in focal epilepsy;Eeg-Olofsson O;Acta Neurol Scand,1988
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献