Continuous flow Aza-Michael reaction for preparing the fast-acting synthetic opioid drug Remifentanil
Author:
Affiliation:
1. Universidade de São Paulo, Brazil
2. Universidade de São Paulo, Brazil; Avita Produtos Químicos e Farmacêuticos LTDA, Brazil
Publisher
FapUNIFESP (SciELO)
Link
http://www.scielo.br/scielo.php?script=sci_pdf&pid=S1984-82502023000100383&tlng=en
Reference18 articles.
1. On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system;Adamo A;Science (80-),2016
2. Process intensification for obtaining a cannabidiol intermediate by Photo-oxygenation of limonene under continuous-glow conditions;Aguillon A;Org Process Res Dev,2020
3. Continuous one-flow multi-step synthesis of active pharmaceutical ingredients;Bloemendal VRLJ;React Chem Eng,2020
4. Remifentanil: A novel, short-acting, μ-opioid;Bürkle H;Anesth Analg,1996
5. Why flow means green-Evaluating the merits of continuous processing in the context of sustainability;Dallinger D;Curr Opin Green Sustain Chem,2017
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