Affiliation:
1. Santa Casa de Belo Horizonte
Abstract
Antithyroglobulin antibodies (TgAb) were measured using a chemiluminescent immunoassay (ICMA) and an agglutination test. TgAb laboratory and clinical interference with Tg measurements were assessed. The course of TgAb concentration and disease status were compared during 3 years after initial treatment. The agglutination test failed to detect all titers < 10IU/mL (ICMA). Interference from TgAb was common at high titers, but even low antibody titers (< 5IU/mL) were able to interfere with Tg measurement. Cases of distant metastases with undetectable Tg (by IRMA) and those apparently free of disease and without thyroid remnants with Tg> 2ng/ml (by RIA) were identified among patients with TgAb. The exogenous Tg recovery test was normal (> 80%) by the two methods in 22% of patients with TgAb and confirmed laboratory interference. Absence of reduction in TgAb levels was a marker of persistent disease. In conclusion, TgAb should be determined by immunoassays; interference with Tg measurements occurred mainly but not always at high concentrations, with a normal Tg recovery test not excluding this interference. The behavior of TgAb is related to disease persistence or cure.
Subject
General Medicine,Endocrinology, Diabetes and Metabolism
Reference22 articles.
1. Serum thyroglobulin in the follow-up of patients with treated differentiated thyroid cancer;Ozata M;J Clin Endocrinol Metab,1994
2. Serum thyroglobulin determination in the follow-up of patients with differentiated thyroid carcinoma;Schlumberger M;Eur J Endocrinol,1998
3. Medical progress-papillary and follicular thyroid carcinoma;Schlumberger MJ;N Engl J Med,1998
4. A comparison of recombinant human thyrotropin and thyroid hormone withdrawal for the detection of thyroid remnant or cancer;Haugen BR;J Clin Endocrinol Metab,1999
5. A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma;Mazzaferri EL;J Clin Endocrinol Metab,2003
Cited by
46 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献