Scanning electron microscopy of acantholysis in pemphigus foliaceus

Author:

Almeida Jr. Hiram Larangeira de1,Leitao Aline Hatzenberger2,Rossi Gabriela2,Rocha Nara Moreira3,Silva Ricardo Marques e1

Affiliation:

1. Federal University of Pelotas, Brazil

2. Catholic University of Rio Grande do Sul, Brazil

3. Empresa Brasileira de Pesquisa Agropecuaria, Brazil

Abstract

We performed scanning electron microscopy of an inverted blister roof in a case of pemphigus foliaceus. The loss of intercellular adherence could be easily seen with low magnification. The acantholytic keratinocytes displayed an irregular and sometimes polygonal contour. Round cells, typically seen in light microscopy, were also observed. The examination of a blister roof allows ultrastructural documentation of the acantholytic changes.

Publisher

FapUNIFESP (SciELO)

Subject

Dermatology

Reference6 articles.

1. The desmosome and pemphigus;Waschke J;Histochem Cell Biol,2008

2. Pemphigus foliaceus IgG causes dissociation of desmoglein 1-containing junctions without blocking desmoglein 1 transinteraction;Waschke J;J Clin Invest,2005

3. Significance of epitope spreading in the pathogenesis of pemphigus vulgaris and foliaceus;Aoki V;An Bras Dermatol,2008

4. The ultrastructure of acantholysis in pemphigus vulgaris;Diercks GF;Br J Dermatol,2009

5. Desmosome splitting is a primary ultrastructural change in the acantholysis of pemphigus;Wang W;J Dermatol Sci,2009

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