Exploring the frequency of a TP53 polyadenylation signal variant in tumor DNA from patients diagnosed with lung adenocarcinomas, sarcomas and uterine leiomyomas

Author:

Vieira Igor Araujo1ORCID,Viola Guilherme Danielski2,Pezzi Eduarda Heidrich3,Kowalski Thayne Woycinck4,Fernandes Bruna Vieira3,Andreis Tiago Finger2,Bom Natascha5,Sonnenstrahl Giulianna5,Rocha Yasminne Marinho de Araújo3,Corrêa Bruno da Silveira3ORCID,Donatti Luiza Mezzomo6,Sant’Anna Gabriela dos Santos7,Corleta Helena von Eye8,Brum Ilma Simoni6,Rosset Clévia9ORCID,Vianna Fernanda Sales Luiz10ORCID,Macedo Gabriel S.11,Palmero Edenir Inez12ORCID,Ashton-Prolla Patricia13ORCID

Affiliation:

1. Universidade Federal do Rio Grande do Sul, Brazil; Hospital de Clínicas de Porto Alegre, Brazil; Universidade do Vale do Rio dos Sinos, Brazil

2. Universidade Federal do Rio Grande do Sul, Brazil; Hospital de Clínicas de Porto Alegre, Brazil

3. Hospital de Clínicas de Porto Alegre, Brazil

4. Universidade Federal do Rio Grande do Sul, Brazil; Hospital de Clínicas de Porto Alegre, Brazil; Universidade Federal do Rio Grande do Sul, Brazil; Instituto Nacional de Genética Médica Populacional, Brazil; Hospital de Clínicas de Porto Alegre, Brazil; Complexo de Ensino Superior de Cachoeirinha, Brazil

5. Universidade do Vale do Rio dos Sinos, Brazil

6. Universidade Federal do Rio Grande do Sul, Brazil; Universidade Federal do Rio Grande do Sul, Brazil

7. Universidade Federal do Rio Grande do Sul, Brazil

8. Universidade Federal do Rio Grande do Sul, Brazil; Hospital de Clínicas de Porto Alegre, Brazil; Universidade Federal do Rio Grande do Sul, Brazil

9. Hospital de Clínicas de Porto Alegre, Brazil; Universidade Federal do Rio Grande do Sul, Brazil; Hospital de Clínicas de Porto Alegre, Brazil

10. Universidade Federal do Rio Grande do Sul, Brazil; Hospital de Clínicas de Porto Alegre, Brazil; Universidade Federal do Rio Grande do Sul, Brazil; Instituto Nacional de Genética Médica Populacional, Brazil; Hospital de Clínicas de Porto Alegre, Brazil; Universidade Federal do Rio Grande do Sul, Brazil; Universidade Federal do Rio Grande do Sul, Brazil

11. Universidade Federal do Rio Grande do Sul, Brazil; Hospital de Clínicas de Porto Alegre, Brazil; Hospital de Clínicas de Porto Alegre, Brazil

12. Instituto Nacional de Câncer, Brazil; Hospital de Câncer de Barretos, Brazil

13. Universidade Federal do Rio Grande do Sul, Brazil; Hospital de Clínicas de Porto Alegre, Brazil; Universidade Federal do Rio Grande do Sul, Brazil; Hospital de Clínicas de Porto Alegre, Brazil; Hospital de Clínicas de Porto Alegre, Brazil

Publisher

FapUNIFESP (SciELO)

Reference32 articles.

1. Analysis of predictive biomarkers in patients with lung adenocarcinoma from southern Brazil reveals a distinct profile from other regions of the country;Andreis TF;J Glob Oncol,2019

2. The impact of rare and low-frequency genetic variants in common disease;Bomba L;Genome Biol,2017

3. Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant;Deng Q;Nat Commun,2019

4. Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits;Di Giovannantonio M;J Med Genet,2021

5. The dark matter of the cancer genome: Aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations;Diederichs S;EMBO Mol Med,2016

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