Affiliation:
1. University of Groningen, The Netherlands
2. University of Groningen, The Netherlands; 'Sapienza' University of Rome, Italy
Abstract
In the last few decades, a number of radiopharmaceuticals for imaging inflammation have been proposed that differ in their specificity and mechanism of uptake in inflamed foci as compared to the traditional inflammation imaging agents. Radiolabelled cytokines represent a reliable tool for the preclinical diagnosis of chronic inflammatory processes, even before anatomical and functional changes occur in affected tissues. Moreover, the introduction of radiolabelled monoclonal antibodies and sophisticated technique like PET/CT now make the field of inflammation imaging highly specific and accurate. In this review, different approaches of the established and experimental radiopharmaceuticals for imaging of chronic inflammation are discussed.
Reference88 articles.
1. Technetium-99m-human polyclonal IgG radiolabelled via the hydrazino nicotinamide derivative for imaging focal sites of infection in rats;Abrams M. J.;J. Nucl. Med.,1990
2. Radiolabelling of a monoclonal anti-TNF-alpha antibody with 99mTc: in vitro studies;Annovazzi A.;Q. J. Nucl. Med. Mol. Imaging,2002
3. [11C](R)-PK11195 positron emission tomography imaging of activated microglia in vivo in Rasmussen's encephalitis;Banati R. B.;Neurology,1999
4. The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity;Banati R. B.;Brain,2000
5. 99mTc-IL-2 scintigraphy in patients with cutaneous melanoma: detection of lymphocytic infiltration;Barone R.;Eur. J. Nucl. Med.,1998
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