Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy

Author:

Pereira Kércia Regina Santos Gomes1,Açucena Maria Kadja Meneses Torres1,Villarim Neto Arthur1,Rêgo Amália Cínthia Meneses1,Bernardo-Filho Mário2,Azevedo Ítalo Medeiros1,Araújo Filho Irami1,Medeiros Aldo Cunha1

Affiliation:

1. Universidade Federal do Rio Grande do Norte, Brazil

2. Universidade do estado do Rio de Janeiro, Brazil

Abstract

Drugs and surgery can interfere with the biodistribution of radiopharmaceuticals and data about the effect of splenectomy on the metabolism of phytate-Tc-99m are scarce. This study aimed at evaluating the interference of splenectomy on phytate-Tc-99m biodistribution and liver function in rats. The SP group rats (n=6) underwent splenectomy. In group C (control) the animals were not operated on. After 15 days, all rats were injected with 0.1mL of Tc-99m-phytate via orbital plexus (0.66MBq). After 30 minutes, liver samples were harvested, weighed and the percentage of radioactivity per gram (%ATI/g) was determined by a Wizard Perkin-Elme gama counter. The ATI%/g in splenectomized rats (0.99±0.02) was significantly higher than in controls (0.4±0.02), (p=0.034). ALT, AST and HDL were significantly lower in SP rats (p= 0.001) and leukocytosis was observed in SP rats. In conclusion, splenectomy in rats changed the hepatic biodistribution of Tc-99m-phytate and liver enzimatic activity.

Publisher

FapUNIFESP (SciELO)

Subject

Multidisciplinary

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