Comparison of fentanil or remifentanil prolonged continuous infusion in dogs undergoing elective ovariohysterectomy

Author:

Conterno Gabriela Borges1ORCID,Ronchi Samuel Jorge1ORCID,Comassetto Felipe1ORCID,Rosa Luara da1ORCID,Baron Mariana1ORCID,Sabino Karoline Simião1ORCID,Oleskovicz Nilson1ORCID

Affiliation:

1. Universidade do Estado de Santa Catarina (UDESC), Brazil

Abstract

ABSTRACT: It aimed to compare the trans anesthetic clinical and perioperative analgesic effects by prolonged continuous infusion of fentanyl (GF, bolus of 5 µg/kg and continuous infusion (CI) of 15 µg/kg/h) or remifentanil (GR, CI of 18 µg/kg/h) in dogs undergoing to elective ovariohysterectomy. Twenty female healthy dogs were premedicated with acepromazine, inducted to unconsciousness with propofol and kept under anesthesia with isoflurane. The M0 (baseline) was recorded and animals were randomly allocated in GF (n = 10) or GR (n = 10), recording clinical and blood gas parameters every 15 minutes (M15…M120) for two hours and, after, during surgery, adjusting the opioid rate according to surgical requirement. The isoflurane vaporization reduced by up to 47% and 42% in GF and GR, respectively, when compared to M0. During the first two hours of CI, six animals of each group required atropine intervention and three animals of GF required ephedrine. The number of rate adjustments during intraoperative was significant higher in GR when compared to GF (P = 0.0248). By the Log-rank test, there was a higher possibility of not receiving analgesic rescue in the first 30 minutes of postoperative in GF when compared to GR (P < 0.0001) and all animals required analgesic rescue during the firsts 3 and 6 hours in GR and GF, respectively. It is concluded that, when the proposal continuous infusions were compared, fentanyl required fewer analgesic rescues during perioperative, nonetheless, it is recommended rate adjustment during intraoperative and additional analgesia for postoperative for both treatments.

Publisher

FapUNIFESP (SciELO)

Reference28 articles.

1. Epidural levobupivacaine alone or combined with different morphine doses in bitches under continuous propofol infusion;ALBUQUERQUE V. B.;Arquivo Brasileiro de Medicina Veterinaria e Zootecnia,,2015

2. The isoflurane-sparing and clinical effects of a constant rate infusion of remifentanil in dogs.;ALLWEILER S.;Veterinary Anaesthesia and Analgesia,2007

3. Avaliação da concentração expirada de isoflurano em infusão continua de remifentanil em cadelas submetidas a mastectomia.;BEIER S. L.;Semina: Ciências Agrárias,2015

4. Reduction of isoflurane MAC by fentanyl or remifentanil in rats.;CRIADO A. B.;Veterinary Anaesthesia and Analgesia,2003

5. Anesthetic potency and influence of morphine and sevoflurane on respiration in mu-opioid receptor knockout mice. Erratum appears in Anesthesiology 2001;DAHAN A.;Anesthesiology,2001

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3