Anthelmintic acetogenin from Annona squamosa L. Seeds

Author:

Souza Marta M.C.1,Bevilaqua Claudia M.L.1,Morais Selene M.2,Costa Cícero T.C.1,Silva Ana R.A.2,Braz-Filho Raimundo3

Affiliation:

1. Universidade Estadual do Ceará

2. Universidade Estadual do Ceará, Brasil

3. Universidade Estadual do Norte Fluminense, Brasil

Abstract

Annona squamosa seeds extracts showed anthelmintic activity against Haemonchus contortus, the main nematode of sheep and goat in Northeastern Brazil. A compound 1 was isolated from ethyl acetate extract and inhibited the egg hatching of H. contortus at 25 mg ml-1. The structure of 1 was determined as a C37 trihydroxy adjacent bistetrahydrofuran acetogenin based on spectroscopic analysis.

Publisher

FapUNIFESP (SciELO)

Subject

Multidisciplinary

Reference20 articles.

1. Annonaceous Acetogenins: Recent Progress;ALALI FQ;J Nat Prod,1999

2. In vitro screening of two Nigerian medicinal plants (Vernonia amygdalina and Annona senegalensis) for anthelmintic activity;ALAWA CBI;Vet Parasitol,2003

3. Squamocin-O1 and squamocin-O2, new adjacent bis-tetrahydrofuran acetogenins from the seeds of Annona squamosa;ARAYA H;Phytochemistry,2002

4. Seasonal veriations of gastrointestinal nematodes in sheep and goats from semi-arid area in Brazil;AROSEMENA NAE;Rev Med Vet,1999

5. Ovicidal and larvicidal activity in vitro of Spigelia anthelmia Linn. extracts on Haemonchus contortus;ASSIS LM;Vet Parasitol,2003

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