Affiliation:
1. Federal University of Rio Grande do Norte, Brazil
Abstract
Abstract This study aimed to detect, quantify and compare the immunohistochemical expression of EGFR and VEGF and microvessel count (MVC) in oral lipomas, and to correlate the findings with clinical and morphological characteristics of the cases studied. The sample consisted of 54 oral lipomas (33 classic and 21 non-classic) and 23 normal adipose tissue specimens. Cytoplasmic and/or nuclear immunohistochemical staining of EGFR and VEGF was analyzed. The angiogenic index was determined by MVC. Cells were counted using the Image J® software. The Statistical Package for the Social Sciences was used for data analysis, adopting a level of significance of 5% for all statistical tests. A statistically significant difference in EGFR immunoexpression (p=0.047), especially, between classic lipomas and normal adipose tissue. There was a significant difference in MVC between non-classic lipomas and normal adipose tissue (p=0.022). In non-classic lipomas, only VEGF immunoexpression showed a significant moderate positive correlation (r=0.607, p=0.01) with MVC. In classic lipomas, the number of EGFR-immunostained adipocytes was directly proportional to the number of VEGF-positive cells, demonstrating a significant moderate positive correlation (r=0.566, p=0.005). The results suggest that EGFR, VEGF, and angiogenesis participate in the development of oral lipomas but are not primarily involved in the growth of these tumors.
Reference34 articles.
1. Giant oral lipoma: a rare entity;Ponce JB;An Bras Dermatol,2016
2. A Research of Soft Tissue Lipoma Genesis Factor With Immunohistochemical Analysis;Lee JB;J Craniofac Surg,2017
3. Intraoral lipomas: A clinicopathological study of 43 cases, including four cases of spindle cell/pleomorphic subtype;Linares MF;Med Oral Patol Oral Cir Bucal,2019
4. Lipomas of the oral cavity: clinical and histopathologic study of 41 cases in a Brazilian population;Juliasse LE;Eur Arch Otorhinolaryngol,2010
5. Extra-Oral Excision of a Buccal Fat Pad Lipoma;Trento GDS;J Craniofac Surg,2017